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Contains Phosphatidyl Serine, Phosphatidyl choline,L- pyroglutamate that are precursor to neurotransmitter acetylcholine involved in transmission of messages from one nerve cell to another that may help with memory and concentration .It also contains antioxidants , anti-inflammatory ,Vitamins and free radicals scavengers that helps to protect neurons from frequent damages.
CoQ10 (ubiquinone): is a powerful antioxidant that buffers the potential adverse consequences of free radicals produced during oxidative phosphorylation in the inner mitochondrial membrane.It protects against neuronal damage and increases brain mitochondrial concentration and exerts neuroprotective effects. CoQ10 is safe and is clinically effective neuroprotectant.
Bioperine (Piper longum): Piperine, the active principle of Piper longum enhanced the bioavailability of phenytoin significantly, possibly by increasing the absorption .it also possesses thyrogenic activity
Ginger root: It possesses analgesic, antiinflammatory and hypoglycaemic properties;It is also used in the management of painful, arthritic inflammatory conditions
L-Serine: D-serine, an amino acid synthesized from L- serine serves as neuromodulators
Phosphatidylserine (PtdSer): is a ubiquitous phospholipid species that is normally located within the inner leaflet of the cell membrane. PtdSer supplementation on humans has concentrated on memory and cognitive function
Phosphatidylcholine (Soybean phospholipids): Soybean phospholipids may increase contents of protein, PUFA and PL in brain of mice and improve learning and memory abilities
Choline : Choline is an essential nutrient; deficiency of which leads to impaired liver function, elevated blood concentrations of alanine aminotransferase, creatinine phosphokinase and homocysteine and depletion of acetylcholine concentration in the brain, leading to deficit in memory function.
Hawthorn Berry: Hawthorn (Crataegus oxyacantha) is a fruit-bearing shrub with a long history as a medicinal substance was used by european herbalist in the first century A. D. It helps with positive inotropic activity, ability to increase the integrity of the blood vessel wall and improve coronary blood flow, and positive effects on oxygen utilization.
Royal jelly: Royal jelly will act as a medicinal food in the human body when hydrolysed it possess antioxidative activities and scavenging activities against active oxygen species
L- pyroglutamate: Is a precursor to neurotransmitter
Gotu Kola: It has been used for centuries in Ayurvedic and traditional Chinese medicine to alleviate symptoms of depression and anxiety.
Vitamin C: Ascorbyl palmitate (AP), a bioactive, lipid-soluble ester of ascorbic acid (AA), has the ability to penetrate neural tissues and help to transport ascorbate into it
Folic Acid: Folate deficiency induces neurotoxicity by multiple routes, including increasing cytosolic calcium and oxidative stress via increasing levels of the neurotoxin homocysteine (HC), and inducing mitochondrial and DNA damage. Supplementation with folic acid can provide cognitive benefits in some circumstances.
Vitamin B12: Vitamin B12, is directly involved in the synthesis of some neurotransmitters. Supplementation with cobalamin improves cerebral , the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer's disease and vascular dementia in elderly people.it frequently improves the functioning of factors related to the frontal lobe, as well as the language function of those with cognitive disorders. Adolescents who have a borderline level of vitamin B12 develop signs of cognitive changes.
L-Glutamine: Glutamine synthetase (GS) is involved in important processes in brain: modulation of the turnover of glutamate through the glutamate-glutamine cycle, detoxification of ammonia and, under certain circumstances, modulation of brain edema. Modulation of GS activity in brain is therefore important and its impairment or saturation may have pathological consequences.
Gingko Biloba: Ginkgo biloba from the traditional Chinese system of medicine has been found to possess neurocognitive enhancing effects.Ginkgo biloba exerts many pharmacological actions. It possesses antioxidant properties, the ability of neurotransmitter/receptor modulation and antiplatelet activation factor. Ginkgo biloba leaf extract (Ginaton) could improve cerebral oxygen supply, promote SOD activity to inhibit production of free radicals in patients undergoing cardiopulmonary bypass (CPB), and thus shows an evident protective effect in the brain.
Korean Red Ginseng Root: This plant is a promising candidate of neuroprotective effects and would be useful for the treatment of the neuronal degenerative diseases such as Alzheimer's diseases. Panax ginseng is marketed and used to maintain natural energy, increase mental and physical abilities, improve mood and promote general health and well-being.
Acetyl-L-carnitine (ALC): poses unique neuroprotective, neuromodulatory, and neurotrophic properties, which may play an important role in counteracting various diseases. It also has some beneficial effects in the treatment of ADHD children.
DMAE: A vitamin-mineral drug combination containing DMAE can be interpreted to induce a psychophysiological state of better feeling of well being on both levels of analysis mood and electrical pattern of brain activity in subjects suffering from borderline emotional disturbance.It has also produced significant improvements in working memory performance.
Taurine: is an important antioxidant helpful in the regulation of neuronal Ca2+ signaling and it’s deficiency may predispose one to nerve hyperexcitability and pain, complicating diabetes. It also reverses neurological and neurovascular deficits
Elutherococecus senticosus root extract: this lowers the occurrence and/or multiplicity of tumors (mainly those of the central nervous system).
References:
CNS Spectr. 2007 Jan;12(1):62-8.
Young AJ, Johnson S, Steffens DC, Doraiswamy PM. Duke University Medical Center, Durham, NC, USA.
Pattanaik S, Hota D, Prabhakar S, Kharbanda P, Pandhi P. Department of Pharmacology, Research Block B, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
Vijayakumar RS, Nalini N. Department ofBiochemistry and Biotechnology, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.
Phytother Res. 2006 Sep;20(9):764-72
Martineau M, Baux G, Mothet JP. Laboratoire de Neurobiologie Morphofonctionnelle, INSERM U378, 146 Rue Leo Saignat, 33077 Bordeaux, France.
Kingsley M. Department of Sports Science, University of Wales Swansea, Singleton Park, Swansea, UK. M.I.C.Kingsley@Swansea.ac.uk
Gong J, Shi F, Shao L, Zheng X. College of Chemistry and Life Sciences Zhejiang Normal University, Jinhua 321004, China.
Gossell-Williams M, Benjamin J. Department of Basic Medical Sciences, The University of the West Indies, Kingston 7, Jamaica, West Indies. maxine.gossell@uwimona.edu.jm
Rigelsky JM, Sweet BV. H. H. McGuire Veterans Affairs Medical Center, Richmond, VA, USA.
Nagai T, Inoue R, Suzuki N, Nagashima T. Department of Food Science and Technology, Tokyo University of Agriculture, Hokkaido, Japan. t1nagai@bioindustry.nodai.ac.jp
Bradwejn J, Zhou Y, Koszycki D, Shlik J.Royal Ottawa Hospital and the Department of Psychiatry, University of Ottawa, Ontario, Canada. jbradwej@rohcg.on.ca
Pokorski M, Marczak M. Department of Respiratory Research, Medical Research Center, Polish Academy of Science, Warsaw, Poland. mpokorski@cmdik.pan.pl.J Physiol Pharmacol. 2005 Sep;56 Suppl 4:197-201.
Pokorski M, Marczak M, Dymecka A, Suchocki P. Department of Respiratory Research, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland, J Biomed Sci. 2003 Mar-Apr;10(2):193-8
Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB. Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA.Aging Cell. 2004 Apr;3(2):71-6
D'Anci KE, Rosenberg IH. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA.Curr Opin Clin Nutr Metab Care. 2004 Nov;7(6):659-64
Bourre JM.French Academy of Medicine. INSERM, U705 ; CNRS, UMR 7157 ; Universites Paris 7 et 5, Department of Neuro-pharmaco-nutrition. Hopital Fernand Widal, 200, rue du Faubourg Saint-Denis, 75475 Paris cedex 10. jean-marie.bourre@fwidal.inserm.frJ Nutr Health Aging. 2006 Sep-Oct;10(5):377-85.
Reynolds E.Institute of Epileptology, King's College, Denmark Hill Campus, Cutcombe Road, London, SE5 6PJ, UK. reynolds@buckles.u-net.comLancet Neurol. 2006 Nov;5(11):949-60.
Rodrigo R, Felipo V. Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Fundacion de la Comunidad Valenciana Centro de Investigacion Principe Felipe, Valencia, Spain.
Front Biosci. 2007 Jan 1;12:883-90.
Chung SY, Cheng FC, Lee MS, Lin JY, Lin MC, Wang MF. Department of Food and Nutrition, Providence University, 433 Taichung, Taiwan, ROC.Am J Chin Med. 2006;34(5):803-17.
Deng YK, Wei F, Zhang DG. Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang. dyk126@163.comZhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Sep;26(9):795-8.
Kim ST, Kim JD, Lyu YS, Lee MY, Kang HW. Nano-Bio of Research Institute, Division of Nanoscience, Department of Nature Science, Ewha Womans University, Sedaemoon-Gu, Seoul, Korea. lingokst@ewha.ac.krBiol Pharm Bull. 2006 Oct;29(10):2021-4.
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Adriani W, Rea M, Baviera M, Invernizzi W, Carli M, Ghirardi O, Caprioli A, Laviola G. Behavioural Neuroscience Section, Dept. Cell Biology & Neurosciences, Istituto Superiore di Sanita', viale Regina Elena 299, 00161 Rome, Italy.
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Supplement Facts
Serving Size: 1 Vegetarian Tablet |
| |
Amount Per
Serving |
% Daily
Value |
Vitamin C
(as 12.5 mg of ascorbyl palmitate) |
5 mg |
8 |
| Folic Acid |
50 mcg |
12 |
| Vitamin B12 (100% as dibencozide) |
50 mcg |
833 |
| L-Glutamine |
75 mg |
* |
| Acetyl-L-Carnitine |
50 mg |
* |
| DMAE (dimethylaminoethanol) |
50 mg |
* |
Ginkgo Biloba Standardized Extract
(24% ginkgoflavonglycosides and 6% terpene lactones) |
50 mg |
* |
| L-Pyroglutamate |
50 mg |
* |
| Choline (from choline bitartrate) |
35 mg |
* |
| Gotu Kola Herb (Centella asiatica) |
25 mg |
* |
Hawthorn Berry
(Crataegus laevigata) |
25 mg |
* |
Korean Red Ginseng Root
(Panax ginseng) |
25 mg |
* |
| L-Taurine |
25 mg |
* |
Royal Jelly Extract
(contains minimum 1.6% 10-Hydroxy-2-Deconoic Acid) |
25 mg |
* |
Eleutherococcus senticosus
Root 50:1 Extract |
25 mg |
* |
Phosphatidyl Choline
(from soybean lecithin) |
25 mg |
* |
| Phosphatidyl Serine |
15 mg |
* |
| Coenzyme Q10 |
10 mg |
* |
| L-Serine |
5 mg |
* |
| Ginger Root (Zingiber officinale) |
3 mg |
* |
| Bioperine® |
1 mg |
* |
| † - % Daily Value * - Daily Value Not Established |
Other Ingredients: Cellulose, deep mined calcium phosphates, fructose, vegetable stearates, orange juice, magnesium stearate, silica, and nicotinate.
NO corn, salt, yeast, gluten, milk & egg products, sucrose, starch or preservatives.
Directions
One tablet per day
Warnings
Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a licensed physician and/or pharmacist prior to taking dietary supplements
Double safety sealed with an outer shrink wrap film and an inner bottle freshness seal. Do not use if either seal is broken or missing. Store in a cool, dry place.
Disclaimer
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. |
